Papers

[2024]​

1. Kuk MU*, Kim D*, Lee YH, Yoon JH, Park JH, Lee YJ, So B, Kim MS, Kwon HW, Byun Y†, Park JT† (Nov 28, 2024) Synergistic ROS Reduction Through the Co-Inhibition of BRAF and p38 MAPK Ameliorates Senescence. (*: co-first author, †: co-corresponding author) Antioxidants 13(12): 1465 [PubMed][pdf]

2. Kuk MU, So MK, Park JH, Yoon JH, Lee YJ, Kim D, So B, Lee YH, Kim M, Byun Y, Kwon HW†, Park JT† (Oct 03, 2024) ROSA26 BAC-based System Enables Continuous High-yield Protein Production. (†: co-corresponding author) Biotechnology and Bioprocess Engineering 10.1007/s12257-024-00158-7 [PubMed][pdf]

3. Yoon JH*, Kim YH*, Jeong EY‡, Lee YH‡, Byun Y, Shin SS†, Park JT† (Sep 10, 2024) Senescence rejuvenation through reduction of mitochondrial ROS generation by Polygonum cuspidatum extract: in vitro evidence (*: co-first author, ‡: co-second author, †: co-corresponding author) Antioxidants accepted [PubMed][pdf]

4. Lee YH*, Kuk MU*, Park JH*, Lee H, Lee H, So MK, Yoon JH, Lee YJ, Kim D, So B, Kim MS, Park J, Han T†, Park JT† (Sep 05, 2024) Rapid and accurate ecotoxicological assessment of heavy metals using Cyprinus carpio cells (*: co-first author, †: co-corresponding author) Life 14(9): 1119 [PubMed][pdf]
5. Lee YH, So BH, Lee KS, Kuk MU, Park JH, Yoon JH, Lee YJ, Kim DY, Kim MS, Kwon HW, Byun Y†, Lee KY†, Park JT† (Sep 05, 2024) Identification of cellular isoschaftoside-mediated anti-senescence mechanism in RAC2 and LINC00294 (†: co-corresponding author) Molecules 29(17): 4182 [PubMed][pdf]

6. Song ES, Lee YH, So MK, Kuk MU, Park J, Yoon JH, Lee YJ, Kim D, So B, Byun Y, Kwon HW†, Park JT† (Mar 05, 2024) Establishment of a new promoter trapping vector using 2A peptide. (†: co-corresponding author) Biotechnology and Bioprocess Engineering  10.1007/s12257-024-00096-4 [PubMed][pdf]

7. Lim JS, Jeon EJ, Go HS, Kim H, Kim KY, Nguyen T, Lee DY, Kim KS, Pietrocola F, Hong SH, Lee SE, Kim K, Park TS, Choi D, Jeong Y, Park Jong, Kim HS, Min J, Kim YS, Park JT, Cho J, Lee G, Lee JH, Choy HE, Park SC, Lee C, Rhee JH, Serrano M, Cho KA (Jan 02, 2024) Mucosal TLR5 activation controls healthspan and longevity. Nature Communications 15(1):46 [PubMed][pdf]

8. Lee YH, Kuk MU, So MK, Park HJ, Song ES, Park J, Yoon JH, Kwon HW†, Choi J†, Park JT† (Nov 14, 2023) Polyporus ulleungus mycelia cultured in MEB medium produce metabolites with anticancer property. (†: co-corresponding author) Journal of Cancer (2022 Journal Impact factor: 4.478) 15(2):309-316 [PubMed][pdf]

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[2023]​

1. Song ES, So MK, Park HJ, Lee H,  Lee YH, Kuk MU, Park J, Kwon HW, Choi J†, Park JT† (Jul 09, 2023) Chemical screening identifies the anticancer properties of Polyporous tuberaster. (†: co-corresponding author) Journal of Cancer (2022 Journal Impact factor: 4.478) 14(11): 2075-2084 [PubMed][pdf]

2. Lee YH*, Kuk MU*, So MK, Song ES, Lee H, Ahn S, Kwon HW†, Park JT†, Park SC† (Apr 15, 2023) Targeting Mitochondrial Oxidative Stress as a Strategy to Treat Aging and Age-Related Diseases. (*: co-first author, †: co-corresponding author) Antioxidants (2022 Journal Impact factor: 7.675) 12:934 [PubMed][pdf]

3. Lee H, Song ES, Lee YH, Park JY, Kuk MU, Kwon HW, Roh H†, Park JT† (Feb 07, 2023) A novel hybrid promoter capable of continuously producing proteins in high yield. (†: co-corresponding author) Biochemical and Biophysical Research Communications (2022 Journal Impact factor: 3.322) 650: 103-108 [PubMed][pdf]

4. Kuk MU, Lee H, Song ES, Lee YH, Park JY, Jeong S, Kwon HW,  Byun Y†, Park SC†, Park JT† (Jan 16, 2023) Functional restoration of lysosomes and mitochondria through modulation of AKT activity ameliorates senescence. (†: co-corresponding author) Experimental Gerontology (2022 Journal Impact factor: 4.253) 173:112091 [PubMed][pdf]

5. Lee YH, Kim M, Park HJ, Park JY, Song ES, Lee H, Ko G, Ahn S, Kwon HW, Byun Y, Kim C†, Choi J†, Park JT† (Jan 01, 2023) Chemical screening identifies the anticancer properties of Polyporous parvovarius. (†: co-corresponding author) Journal of Cancer (2022 Journal Impact factor: 4.478) 14(1):50-60 [PubMed][pdf]

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[2022]​

1. Park JY, Lee H, Song ES, Lee YH, Kuk MU, Ko G, Byun YJ†, Kwon HW†, Park JT† Improvement of Tol2 transposon system by modification of Tol2 transposase. (†: co-corresponding author) Biotechnology and Bioprocess Engineering (2022 Journal Impact factor: 2.836) 27(6): 987-994 [PubMed][pdf]

2. Choi S, Lee H, Lee M, Park JT, Heynderickx PM, Wu D, Depuydt S, Asselman J, Janssen C, Häder DP, Han T, Park J (Nov 05, 2022) A Ten-Minute Bioassay to Test Metal Toxicity with the Freshwater Flagellate Euglena agilis. Biology (2022 Journal Impact factor: 5.168) 11(11):1618 [PubMed][pdf]

3. Kuk MU, Ga YJ, Kim YJ, Park JY, Song ES, Lee H, Lee YH, Ko G, Kim JK, Yeh JY, Kwon HW†, Byun YJ†, Park JT† (Oct 24, 2022) Metabolic reprogramming as a novel therapeutic target for Coxsackievirus B3. (†: co-corresponding author) Animal Cells and Systems (2022 Journal Impact factor: 1.815) 26(6) 275–28 [PubMed][pdf]

4. Park JY, Lee H, Song ES, Lee YH, Kuk MU, Ko G, Kwon HW†, Byun YJ†, Park JT† (Oct 07, 2022) Restoration of lysosomal and mitochondrial function through p38 MAPK inhibition ameliorates senescence. (†: co-corresponding author) Rejuvenation Research (2022 Journal Impact factor: 4.663)
25(6):291-299 [PubMed][pdf]

5. Yang EJ, Park JH, Cho HJ, Hwang J, Woo S, Park CH, Kim SY, Park JT, Park SC, Hwang D, Lee Y (Jul 14, 2022) Co-inhibition of ATM and ROCK synergistically improves cell proliferation in replicative senescence by activating FOXM1 and E2F1. Commun Biol. 2022 5(1):702 [PubMed][pdf]

6. Lee YH, Park JY, Song ES, Lee H, Kuk MU, Joo JH, Roh H†, Park JT† (Jun 25, 2022) Improvement of Sleeping Beauty transposon system enabling efficient and stable protein production. (†: co-corresponding author) Biotechnology and Bioprocess Engineering 27(3): 353-360 (2022 Journal Impact factor: 2.836) [PubMed][pdf]

7. Kuk MU, Park JY, Song ES, Lee H, Lee YH, Joo JH, Kwon HW†, Park JT† (May 24, 2022) Bacterial artificial chromosome-based protein expression platform using the Tol2 transposon system. (†: co-corresponding author) Biotechnology and Bioprocess Engineering 27(3): 344-352 (2022 Journal Impact factor: 2.836) [PubMed][pdf]​

8. Park JT, Oh S (Mar 03, 2022) The translational landscape as regulated by the RNA helicase DDX3. BMB Rep. 55(3): 125-135 (2021 Journal Impact factor: 4.16) [PubMed][pdf]

9. Lee YH, Choi D, Jang G, Park JY, Song ES, Lee H, Kuk MU, Joo JH, Ahn SK, Byun Y†, Park JT† (Jan 30, 2022) Targeting regulation of ATP synthase 5 alpha/beta dimerization alleviates senescence. (†: co-corresponding author) Aging 14(2):678-707 (2020 Journal Impact factor: 5.682) [PubMed][pdf]

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[2021]​

1. Kuk MU, Lee YH, Kim JW, Hwang SY, Park JY, Song ES, Kwon HW, Oh S, Park JT  (Dec 31, 2021) Rapid and Efficient BAC Recombineering: Gain & Loss Screening System. Biotechnology and Bioprocess Engineering 26(6): 1023-1033 (2020 Journal Impact factor: 2.213) [PubMed][pdf]

2. Lee YH, Park JY, Lee H, Song ES, Kuk MU, Joo JH, Oh S, Kwon HW†, Park JT†, Park SC† (Nov 03, 2021) Targeting mitochondrial metabolism as a strategy to treat senescence (†: co-corresponding author) Cells 10(11): 3003 (2021 Journal Impact factor: 6.600) [PubMed][pdf]

3. Kim JW, Lee YH, Kuk MU, Hwang SY, Kwon HW, Park JT (Oct 31, 2021) Cre/Lox-based RMCE for site-specific integration in CHO cells. Biotechnology and Bioprocess Engineering 26(5): 795-803  (2020 Journal Impact factor: 2.213) [PubMed][pdf]

4. Hwang SY, Lee YH, Kuk MU, Kim JW, Oh S, Park JT (Oct 31, 2021) Improvement of Tol2 transposon system enabling efficient protein production in CHO cells. Biotechnology and Bioprocess Engineering 26(5): 767-775 (2020 Journal Impact factor: 2.213) [PubMed][pdf]

5. Lee HJ, Stephen Depuydt, Shin KS, Choi SY, Kim GH, Lee YH, Park JT, Han TJ, Park JH (Jul 02, 2021), Assessment of various toxicity endpoints in duckweed (Lemna minor) at the physiological, biochemical, and molecular levels as a measure of diuron stress. Biology. 10(7):684 [PubMed][pdf]

6. Park JH, Ryu SJ, Kim BJ, Cho HJ, Park CH, Choi HJC, Jang EJ, Yang EJ, Hwang JA, Woo SH, Lee JH, Park JH, Choi KM, Kwon YY, Lee CK, Park JT, Cho SC, Lee YI, Lee SB, Han JA, Cho KA, Kim MS, Hwang D, Lee YS, Park SC (Jun 29, 2021) Disruption of nucleocytoplasmic trafficking as a cellular senescence driver. Exp Mol Med 53:1092-1108 [PubMed][pdf]

7. Kuk MU, Lee YH, Kim JW, Hwang SY, Park JT†, Park SC† (Feb 17, 2021) Potential Treatment of Lysosomal Storage Disease Through Modulation of the Mitochondrial–Lysosomal Axis. (†: co-corresponding author) Cells. 10(2): 420. (2020 Journal Impact factor: 4.829) [PubMed][pdf]

8. Song N, Jeong DY, Tu TH, Park BS, Yang HR, Kim YJ, Kim JK, Park JT, Yeh JY, Yang S, Kim JG (Feb 04, 2021) Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes. Int J Mol Sci. 22(4):1587 [PubMed][pdf]

9. Park JH, Lee HJ, Choi SY, Pandey LK, Depuydt S, Saeger  JD, Park JT, Han TJ (Jan 04, 2021) Extracts of red seaweed, Pyropia yezoensis, inhibit melanogenesis but stimulate collagen synthesis. Journal of Applied Phycology. 33:653–662 [PubMed][pdf]

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[2020]​

1. Hwang SY, Kuk MU, Kim JW, Lee YH, Lee YS, Choy HE, Park SC, Park JT (Nov 01, 2020) ATM mediated-p53 signaling pathway forms a novel axis for senescence control. Mitochondrion. DOI: 10.1016/j.mito.2020.09.002 (2020 Journal Impact factor: 3.430) [PubMed] [pdf]

2. Lim JS, Lee DY, Kim HS, Park SC, Park JT, Kim HS, Oh WK, Cho KA (Dec 01, 2020) Identification of a novel senomorphic agent, avenanthramide C, via the suppression of the senescence-associated secretory phenotype. Mech Ageing Dev. 192:111355 [PubMed] [pdf]

3. Cho HJ, Yang EJ, Park JT, Kim JR, Kim EC, Jung KJ, Park SC, Lee YS (May 07, 2020) Identification of SYK inhibitor, R406 as a novel senolytic agent. Aging 12(9):8221-8240 (2019 Journal Impact factor: 4.831)[PubMed] [pdf]

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[2019]​

1. Kim JW*, Kuk MU*, Choi HE, Park SC†, Park JT† (Oct 15, 2019) Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence. (*: co-first author, †: co-corresponding author) Exp Gerontol. 126: 110691 (2019 Journal Impact factor: 3.08) [PubMed] [pdf]

2. Oh S, Park JT (May 10, 2019) Zebrafish model of KRAS-initiated pancreatic endocrine tumor. Animal Cells and Systems. 23(3):209-218 (2019 Journal Impact factor: 0.549) [PubMed] [pdf]

3. Kuk MU*, Kim JW*, Lee YS, Cho KA, Park JT†, Park SC† (Mar 31, 2019) Alleviation of senescence via ATM inhibition in accelerated aging models. (*: co-first author, †: co-corresponding author) Mol Cells. 42(3):210-217 (2019 Journal Impact factor: 3.533) [PubMed] [pdf]

4. Kang SU, Park JT (Feb 01, 2019) Functional evaluation of alternative splicing in the FAM190A gene. Genes & Genomics. 41(2):193-199 (2019 Journal Impact factor: 1.188) [PubMed] [pdf]

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[2018]

1. Park JT, Lee YS, Park SC (Nov 25, 2018) Quantification of Autophagy During Senescence. Methods Mol Biol. 1896:149-157 (2019 Journal Impact factor: 0.91) [PubMed] [pdf]

2. Park JT, Leach SD (Oct 08, 2018) Zebrafish model of KRAS-initiated pancreatic cancer. Animal Cells and Systems. 22(6): 353-359 (2019 Journal Impact factor: 0.549) [PubMed] [pdf]

3. Park JT, Lee YS, Cho KA, Park SC (Nov 01, 2018) Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence. Ageing Res Rev. 47:176-182 (2019 Journal Impact factor: 10.39) [PubMed] [pdf]

4. Park JT, Kang HT, Park CH, Lee YS, Cho KA, Park SC (Jun 01, 2018) A crucial role of ROCK for alleviation of senescence-associated phenotype. Exp Gerontol. 106:8-15 (2019 Journal Impact factor: 3.08) [PubMed] [pdf]

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[2017]

1. Kang HT*, Park JT*†, Choi K*, Choi HJ, Jung CW, Lee YS†, ParkSC† (Mar 27, 2017). Chemical screening identifies ATM as a target for alleviating senescence (As co-first and co-corresponding author) Nat Chem Biol. 13:616-623. (2019 Journal Impact factor: 12.154) [PubMed] [pdf]
2. Kang HT*, Park JT*†, Choi K, Choi HJ, Jung CW, Kim GR, Lee YS†, ParkSC† (Jun 01, 2017). Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome (As co-first and co-corresponding author) Aging Cell 16(3):541-550.  (2019 Journal Impact factor: 7.346) [PubMed] [pdf]

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[2016]
1. Jung JG, Shih IM, Park JT, Gerry E, Kim TH, Ayhan A, Handschuh K, Davidson B, Nickles Fader A, Selleri L, Wang TL (Nov 01, 2016). Ovarian cancer chemoresistance relies on the stem cell reprogramming factor PBX1. Cancer Res. 76(21):6351-6361. [PubMed] [pdf]

 

[2015]
1. Park JT, Johnson N, Liu S, Levesque M, Wang YJ, Ho H, Huso D, Maitra A, Parsons MJ, Prescott JD, Leach SD (May 21, 2015). Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey. Oncogene 34(21): 2801–2806. (2019 Journal Impact factor: 6.634) [PubMed] [pdf]
2. Kim MS, Jo S, Park JT, Shin HY, Kim SS, Gurel O, Park SC (Aug 31, 2015). Method To Purify and Analyze Heterogeneous Senescent Cell Populations Using a Microfluidic Filter with Uniform Fluidic Profile. Anal Chem. 87(19):9584-8. [PubMed] [pdf]
3. Wang YJ, Park JT, Parsons MJ, Leach SD (Jun 01, 2015). Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish. Dev Dyn. 244:724-35 [PubMed] [pdf]

 

[2013]
1. Park JT, Leach SD. (Dec 31, 2013) TAILOR (Transgene Activation and Inactivation with LOx and Rox). PLOS ONE 8: e85218 (2019 Journal Impact factor: 2.776) [PubMed] [pdf]
2. Pashos E, Park JT, Leach S, Fisher S (Sep 15, 2013). Distinct enhancers of ptf1a mediate specification and expansion of ventral pancreas in zebrafish. Dev Biol. 381:471-481 [PubMed] [pdf]
3. Choi SM, Kim Y, Shim JS, Park JT, Wang RH, Leach SD, Liu JO, Deng CX, Ye Z, Jang YY (Jun 01, 2013). Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells. Hepatology. 57(6): 2458–2468 [PubMed] [pdf]

 

[2010]
1. Park JT, Chen X, Trope CG,Davidson B, Shih IeM, Wang TL (Sep 01, 2010). Notch3 Overexpression Is Related to the Recurrence of Ovarian Cancer and Confers Resistance to Carboplatin. Am J Pathol. 177(3):1087-94 (2019 Journal Impact factor: 3.762) [PubMed] [pdf]

 

[2008]

1. Park JT, Shih IeM, Wang TL (Nov 01, 2008). Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer. Cancer Res 68(21): 8852-8860 (2019 Journal Impact factor: 8.378) [PubMed] [pdf]

2. Choi JH, Park JT, Davidson B, Morin PJ, Shih IeM, Wang TL (Jul 15, 2008). Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion. Cancer Res. 68(14):5716-23. [PubMed] [pdf]

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[2006]

1. Park JT, Li M, Nakayama K, Mao TL, Davidson B, Zhang Z, Kurman RJ, Eberhart CG, Shih IeM, Wang TL (Jun 15, 2006). Notch3 gene amplification in ovarian cancer. Cancer Res. 66(12):6312-8 (2019 Journal Impact factor: 8.378) [PubMed] [pdf]

 

[2005]
1. Choi KS, Park JT, Dumler JS (Dec 01, 2005) Anaplasma phagocytophilum delay of neutrophil apoptosis through the p38 mitogen-activated protein kinase signal pathway. Infect Immun. 73(12):8209-18. [PubMed] [pdf]

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[2002]

1. Park JT, Jung YE, Ahn TI (Dec 01, 2002) Changes in profiles of major proteins in encysting Acanthamoeba castellanii Korean J. Biol. Sci. 6: 341-347 [PubMed] [pdf]

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Book Chapters

[2009]
1. Park JT, Shih IeM, Wang TL (2009) Targeting Notch Signaling Pathway in Cancer Stem Cell. Cancer Stem Cells Cambridge University Press; 128-138 [pdf]

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Book Translation

[2022]

1. 캠벨 생명과학, 12판 (2022). ㈜바이오사이언스 출판 [LINK]

2. 캠벨 생명과학의 이해, 2nd edition (2022). ㈜바이오사이언스 출판 [LINK]

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[2021]

1.캠벨 생명과학 포커스, 3판 (2021). ㈜바이오사이언스 출판  [LINK]

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[2019]
1. 캠벨 생명과학, 11판 (2019). ㈜바이오사이언스 출판 [LINK]